Alfonso Valencia

2024

• Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection

  Nature Communications

  C. Ávila-Nieto, J. Vergara-Alert, P. Amengual-Rigo, E. Ainsua-Enrich, M. Brustolin, M. Luisa Rodr de la Concepción, N. Pedreño-Lopez, J. Rodon, V. Urrea, E. Pradenas, S. Marfil, E. Ballana, E. Riveira-Muñoz, M. Pérez, N. Roca, F. Tarrés-Freixas, G. Cantero, A. Pons-Grífols, C. Rovirosa, C. Aguilar-Gurrieri, R. Ortiz, A. Barajas, B. Trinité, R. Lepore, J. Muñoz-Basagoiti, D. Perez-Zsolt, N. Izquierdo-Useros, A. Valencia, J. Blanco, V. Guallar, B. Clotet, J. Segalés, and J. Carrillo
• Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches

  Frontiers in Immunology

  A. Niarakis, M. Ostaszewski, A. Mazein, I. Kuperstein, M. Kutmon, M. E. Gillespie, A. Funahashi, M. Luis Acencio, A. Hemedan, M. Aichem, K. Klein, T. Czauderna, F. Burtscher, T. G. Yamada, Y. Hiki, N. F. Hiroi, F. Hu, N. Pham, F. Ehrhart, E. L. Willighagen, A. Valdeolivas, A. Dugourd, F. Messina, M. Esteban-Medina, M. Peña-Chilet, K. Rian, S. Soliman, S. Sadat Aghamiri, B. Lal Puniya, A. Naldi, T. Helikar, V. Singh, M. Fariñas Fernández, V. Bermudez, E. Tsirvouli, A. Montagud, V. Noël, M. Ponce-de-Leon, D. Maier, A. Bauch, B. M. Gyori, J. A. Bachman, A. Luna, J. Piñero, L. I. Furlong, I. Balaur, A. Rougny, Y. Jarosz, R. W. Overall, R. Phair, L. Perfetto, L. Matthews, D. Arokia Bal Rex, M. Orlic-Milacic, L. Cristobal Gomez, B. De Meulder, J. Marie Ravel, B. Jassal, V. Satagopam, G. Wu, M. Golebiewski, P. Gawron, L. Calzone, J. S. Beckmann, C. T. Evelo, P. D’Eustachio, F. Schreiber, J. Saez-Rodriguez, J. Dopazo, M. Kuiper, A. Valencia, O. Wolkenhauer, H. Kitano, E. Barillot, C. Auffray, R. Balling, and R. Schneider
• Roadmap for a European cancer data management and precision medicine infrastructure

  Nature Cancer

  M. Nikolski, E. Hovig, F. Al-Shahrour, N. Blomberg, S. Scollen, A. Valencia, and G. Saunders
• UNCAN.eu: Toward a European Federated Cancer Research Data Hub

  Cancer Discovery

  M. Boutros, M. Baumann, A. Bigas, L. Chaabane, J. Guérin, J. K. Habermann, A. Jobard, P G. Pelicci, O. Stegle, G. Tonon, A. Valencia, E. C. Winkler, P. Blanc, R. De Maria, R. H. Medema, P. Nagy, J. Tabernero, and E. Solary
• Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

  Journal of Translational Medicine

  A. Barajas, P. Amengual-Rigo, A. Pons-Grífols, R. Ortiz, O. Gracia Carmona, V. Urrea, N. de la Iglesia, J. Blanco-Heredia, C. Anjos-Souza, I. Varela, B. Trinité, F. Tarrés-Freixas, C. Rovirosa, R. Lepore, M. Vazquez, L. De Mattos-Arruda, A. Valencia, B. Clotet, C. Aguilar-Gurrieri, V. Guallar, J. Carrillo, and J. Blanco
• Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD

  Am J Respir Crit Care Med .

  N. Olvera, J. Sánchez-Valle, I. Núñez-Carpintero, J. Rojas-Quintero, G. Noell, S. Casas-Recasens, A. Faiz, P. Hansbro, A. Guirao, R. Lepore, D. Cirillo, A. Agustí, F. Polverino, A. Valencia, and R. Faner
• Frustraevo: a web server to localize and quantify the conservation of local energetic frustration in protein familiesAbstract

  Nucleic Acids Research

  G. R. Parra, M. I. Freiberger, M. Poley-Gil, M. Fernandez-Martin, L. G. Radusky, V. Ruiz-Serra, P. G. Wolynes, D. U. Ferreiro, and A. Valencia
• Rare disease research workflow using multilayer networks elucidates the molecular determinants of severity in Congenital Myasthenic Syndromes

  Nature Communications

  I. Núñez-Carpintero, M. Rigau, M. Bosio, E. O'Connor, S. Spendiff, Y. Azuma, A. Topf, R. Thompson, T. Chamova, I. Tournev, V. Guergueltcheva, S. Laurie, S. Beltran, S. Capella-Gutierrez, D. Cirillo, H. Lochmüller, and A. Valencia

2023

• Local energetic frustration conservation in protein families and superfamilies

  Nature Communications

  M. I. Freiberger, V. Ruiz-Serra, C. Pontes, M. Romero-Durana, P. Galaz-Davison, C. A. Ramírez-Sarmiento, C. D. Schuster, M. A. Marti, P. G. Wolynes, D. U. Ferreiro, G. R. Parra, and A. Valencia
• Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant

  Frontiers in Immunology

  C. Ávila-Nieto, J. Vergara-Alert, P. Amengual-Rigo, E. Ainsua-Enrich, M. Brustolin, M. Luisa Rodr de la Concepción, N. Pedreño-Lopez, J. Rodon, V. Urrea, E. Pradenas, S. Marfil, E. Ballana, E. Riveira-Muñoz, M. Pérez, N. Roca, F. Tarrés-Freixas, J. Carabelli, G. Cantero, A. Pons-Grífols, C. Rovirosa, C. Aguilar-Gurrieri, R. Ortiz, A. Barajas, B. Trinité, R. Lepore, J. Muñoz-Basagoiti, D. Perez-Zsolt, N. Izquierdo-Useros, A. Valencia, J. Blanco, B. Clotet, V. Guallar, J. Segalés, and J. Carrillo