Transcriptomics and Functional Genomics Lab (TFGL)

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Showing 1 - 22 results of 22

2024

Cigarette smoking drives accelerated aging across human tissues

bioRxiv

J. MiguelRamírez, R. Ribeiro, O. Soldatkina, A. Moraes, R. García-Pérez, P. G. Ferreira, and M. Melé

2023

Systematic characterization of regulatory variants of blood pressure genes

Cell Genomics

W. Oliveros, K. Delfosse, D. F. Lato, K. Kiriakopulos, M. Mokhtaridoost, A. Said, B. J. McMurray, J. W. L. Browning, K. Mattioli, G. Meng, J. Ellis, S. Mital, M. Melé, and P. G. Maass
Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques

Nature Communications

L. Santus, M. Sopena-Rios, R. García-Pérez, A. E. Lin, G. C. Adams, K. G. Barnes, K. J. Siddle, S. Wohl, F. Reverter, J. L. Rinn, R. S. Bennett, L. E. Hensley, P. C. Sabeti, and M. Melé
Systematic characterization of regulatory variants of blood pressure genes

Cell Genomics

W. Oliveros, K. Delfosse, D. F. Lato, K. Kiriakopulos, M. Mokhtaridoost, A. Said, B. J. McMurray, J. W. L. Browning, K. Mattioli, G. Meng, J. Ellis, S. Mital, M. Melé, and P. G. Maass
Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques

Nature communications

L. Santus, M. Sopena Ríos, R. García-Pérez, A. E. Lin, G. C. Adams, K. G. Barnes, K. J. Siddle, S. Wohl, F. Reverter, J. L. Rin, R. S. Bennet, L. E. Hensley, P. C. Sabet, and M. Melé
The landscape of expression and alternative splicing variation across human traits

Cell Genomics

R. García-Pérez, J. Miguel Ramirez, A. Ripoll-Cladellas, R. Chazarra-Gil, W. Oliveros, O. Soldatkina, M. Bosio, P. Joris Rognon, S. Capella-Gutierrez, M. Calvo, F. Reverter, R. Guigó, F. Aguet, P. G. Ferreira, K. G. Ardlie, and M. Melé
Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation

Clinical Cancer Research

Q. Serra-Camprubí, H. Verdaguer, W. Oliveros, N. Lupión-Garcia, A. Llop-Guevara, C. Molina, M. Vila-Casadesús, A. Turpin, C. Neuzillet, J. Frigola, J. Querol, M. Yáñez-Bartolomé, F. Castet, C. Fabregat-Franco, C. Escudero-Iriarte, M. Escorihuela, E. J. Arenas, C. Bernadó-Morales, N. Haro, F. J. Giles, Ó. J. Pozo, J. M. Miquel, P. G. Nuciforo, A. Vivancos, M. Melé, V. Serra, J. Arribas, J. Tabernero, S. Peiró, T. Macarulla, and T. V. Tian
The landscape of expression and alternative splicing variation across human traits

Cell Genomics

R. García-Pérez, J. Miguel Ramírez, A. Ripoll-Cladellas, R. Chazarra-Gil, W. Oliveros, O. Soldatkina, M. Bosio, P. Joris Rognon, S. Capella-Gutierrez, M. Calvo, F. Reverter, R. Guigó, F. Aguet, P. G. Ferreira, K. G. Ardlie, and M. Melé

2022

Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation

Clinical Cancer Research

Q. Serra-Camprubí, H. Verdaguer, W. Oliveros, N. Lupión-Garcia, A. Llop-Guevara, C. Molina, M. Vila-Casadesús, A. Turpin, C. Neuzillet, J. Frigola, J. Querol, M. Yáñez-Bartolomé, F. Castet, C. Fabregat-Franco, C. Escudero-Iriarte, M. Escorihuela, E. J. Arenas, C. Bernadó-Morales, N. Haro, F. J. Giles, Ó. J. Pozo, J. M. Miquel, P. G. Nuciforo, A. Vivancos, M. Melé, V. Serra, J. Arribas, J. Tabernero, S. Peiró, T. Macarulla, and T. V. Tian
Genetic, parental and lifestyle factors influence telomere lengthAbstract

Communications Biology

S. Andreu-Sánchez, G. Aubert, A. Ripoll-Cladellas, S. Henkelman, D. V. Zhernakova, T. Sinha, A. Kurilshikov, M. Carmen Cenit, M. Jan Bonder, L. Franke, C. Wijmenga, J. Fu, M. G. P. van der Wijst, M. Melé, P. Lansdorp, and A. Zhernakova
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy

npj Genomic Medicine

R. Lesurf, A. Said, O. Akinrinade, J. Breckpot, K. Delfosse, T. Liu, R. Yao, G. Persad, F. McKenna, R. R. Noche, et al.
Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicing

biorxiv

M. Mariotti, C. Kerepesi, W. Oliveros, M. Melé, and V. N. Gladyshev
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy

npj Genomic Medicine

R. Lesurf, A. Said, O. Akinrinade, J. Breckpot, K. Delfosse, T. Liu, R. Yao, G. Persad, F. McKenna, R. R. Noche, W. Oliveros, K. Mattioli, S. Shah, A. Miron, Q. Yang, G. Meng, M. Chan Seng Yue, W. W. L. Sung, B. Thiruvahindrapuram, J. Lougheed, E. Oechslin, T. Mondal, L. Bergin, J. Smythe, S. Jayappa, V. J. Rao, J. Shenthar, P. S. Dhandapany, C. Semsarian, R. G. Weintraub, R. D. Bagnall, J. Ingles, G. England Re Consortium, M. Melé, P. G. Maass, J. Ellis, S. W. Scherer, and S. Mital
In vivo single-cell profiling of lncRNAs during Ebola virus infection

L. Santus, R. García-Pérez, M. Sopena-Rios, A. E. Lin, G. C. Adams, K. G. Barnes, K. J. Siddle, S. Wohl, F. Reverter, J. L. Rinn, R. S. Bennett, L. E. Hensley, P. C. Sabeti, and M. Melé
Genetic, parental and lifestyle factors influence telomere length

Communications Biology

S. Andreu-Sánchez, G. Aubert, A. Ripoll-Cladellas, S. Henkelman, D. V. Zhernakova, T. Sinha, A. Kurilshikov, M. Carmen Cenit, M. Jan Bonder, Lifelines cohort study, L. Franke, C. Wijmenga, J. Fu, M. G. P. van der Wijst, M. Melé, P. Lansdorp, and A. Zhernakova

2021

2020

A Quantitative Proteome Map of the Human Body

Cell

L. Jiang, and et. al.
Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Cell

D. Kotliar, and et. al.
The GTEx Consortium atlas of genetic regulatory effects across human tissues

Science

GTE C.
Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Genome Biology

K. Mattioli, W. Oliveros, C. Gerhanrdinger, A. D, M. PG, J. L. Rinn, and M. Melé

2019

High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue-specificity

Genome Research

K. Mattioli, P-J. Volders, C. Gerhardinger, J. C. Lee, P. G. Maass, M. Melé, and J. L. Rinn