Projects

Liver cirrhosis is a very common and severe chronic disease, responsible for high morbidity, impaired quality of life, major healthcare costs, and poor survival, causing an estimated 170,000 deaths per year in Europe. Liver cirrhosis is preceded by a long period of slowly developing,asymptomatic, liver fibrosis; most commonly caused by non-alcoholic fatty liver disease...

In the previous project, EPIC, we developed a consistent methodological framework for the exploration of disease comorbidity at the molecular level. EPIC provides a first overview of disease interactions from the general level to the one of individual patients. Particularly interesting is the network of patient-subgroups that matches, in a statistically significant manner,...

Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently...

A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal was to identify novel mitochondrial-dependent...