The variants must be provided in a VCF compatible format (VCF/BCF/VCF.GZ). The tool is written in Python and uses BAMSurgeon under the hood to generate the tumorized genomes.
GenomeVariator is a tool for adding genomic variants to an existing genome (in SAM/BAM/CRAM format). Currently supported variants are SNVs, indels and SVs (insertions, deletions, translocations, inversions and duplications). It generates realistic genomes as almost always less than 99% of the original real genome is modified.
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License:
MIT License
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