Transcriptomics and Functional Genomics Lab (TFGL)

Comprender las consecuencias de la variación en la expresión génica es fundamental para descifrar la biología y las enfermedades humanas. Los análisis a gran escala de la expresión génica han revolucionado nuestra comprensión de una miríada de procesos biológicos, permitiéndonos conectar cambios...

The Transcriptomics and Functional Genomics Lab, led by Marta Melé, is interested in understanding how the information encoded in our genome determines gene expression and splicing variation across individuals and tissues. To address this, we use a combination of cutting-edge computational analyses, next generation sequencing, and high-throughput functional...

This project provides a unique opportunity to distinguish how genetics and environment impact gene expression and immune response among people of African ancestry, increasing the understanding of variable risk for both communicable and non-communicable diseases. There are currently only a few available single cell reference biological data of tissues from pediatric healthy...

Gene expression determines the identity of cells and it thus governs the process by which organs and tissues are formed and organized in an individual. Furthermore, differences in gene expression between individuals are known to play a crucial role in determining disease risk. However, the mechanisms of how such differences in gene expression are associated with disease...