A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal was to identify novel mitochondrial-dependent...
Un dels grans reptes de la indústria farmacèutica és la medicina personalitzada. Difícilment una sola molècula esdevindrà un tractament farmacològic amb èxit per a tota la població mundial donada la gran variabilitat genètica natural en la població. Actualment l’elevat índex de...
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium was formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT focused on distinct types of haematopoietic cells from...