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Scientific outputs
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Collaborative projects
In coordination with the National DNA Bank We we are supporting the database of clinical data of 12,000 genotyping cases rheumatoid arthritis, Crohn disease and Psoriasis cases and controls (Julià A, et al. Human Mol. Genet, 2012 21(20):4549-57, Julià A, et al. Gut 2012 in press, and Canela-Xandri, O. et al. Genet. Epidemiol 2012 36(7), 710–716.)
We are collaborating with the MD Paredes in order to set up a protocol to predict high resistance genotypes of HIV-1 protease from real patients using computer simulation.
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We identified a set of genes that functionally connect the insulin-signaling pathway with the biology of the mitochondria, which include Type II Diabetes susceptibility genes (Mercader et al, PLoS Genetics, 2012).
We are currently applying this method to different samples with particular emphasis data coming from Chronic Lymphocytic Leukaemia (CLL) patients within the CLL consortium
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Papers
BLUEPRINT to decode the epigenetic signature written in blood. Nature biotechnology. 2012 ;30(3):224-6.
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nature genetics. 2012 ;44(11):1236-42.
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems. PLoS genetics. 2012 ;8(12):e1003046.