LSF schedules jobs that are based on available resources. There are many resources that are built into LSF, but you can also add your own resources, and then use them same way as built-in resources.
For maximum flexibility, you should characterize your resources clearly enough so that users have satisfactory choices. For example, if some of your machines are connected to both Ethernet and FDDI, while others are only connected to Ethernet, then you probably want to define a resource called fddi and associate the fddi resource with machines connected to FDDI. This way, users can specify resource fddi if they want their jobs to run on machines that are connected to FDDI.