Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.
Authors: Lang, Valérie / Pallara, Chiara / Zabala, Amaia / Lobato-Gil, Sofia / Lopitz-Otsoa, Fernando / Farrás, Rosa / Hjerpe, Roland / Torres-Ramos, Monica / Zabaleta, Lorea / Blattner, Christine / Hay, Ronald / Barrio, Rosa / Carracedo, Arkaitz / Fernandez-Recio, Juan / Rodríguez, Manuel / Aillet, Fabienne
Publication: Mol Oncol
Volume / Pagination: 8 / 1026-42
Paraules clau: Cell Line, Tumor, Humans, Molecular Docking Simulation, Mutagenesis, Site-Directed, Point Mutation, Proteasome Endopeptidase Complex, Protein Multimerization, Proteolysis, Proto-Oncogene Proteins c-mdm2, Transcriptional Activation, Tumor Suppressor Protein p53, Ubiquitination